L-methylmalonyl-CoA mutase converts L-methylmalonyl-CoA to succinyl-CoA in the degradation of propionate 24, an important reaction required for both fat and protein metabolism. Methionine synthase is essential for the synthesis of purines and pyrimidines that form DNA.
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Vitamin B12 serves as a cofactor for methionine synthase and L-methylmalonyl-CoA mutase enzymes. In 24 vitamin B12 deficient patients who were already stabilized on intramuscular (IM) vitamin B12 therapy, single daily doses of intranasal cyanocobalamin for 8 weeks lead to serum vitamin B12 concentrations that were within the target therapeutic range (>200 ng/L) Label. Rapid parenteral administration of vitamin B12 in deficiency related neurological damage prevents the progression of this condition 20. The parenteral administration of vitamin B12 rapidly and completely reverses the megaloblastic anemia and gastrointestinal symptoms of vitamin B12 deficiency. Cells that undergo rapid division (for example, epithelial cells, bone marrow, and myeloid cells) have a high demand for vitamin B12 10. It also plays an important role in fat metabolism, carbohydrate metabolism, as well as protein synthesis. This drug aids in growth, cell reproduction, hematopoiesis, nucleoprotein, and myelin synthesis. Oral products of vitamin B12 are not recommended in patients with malabsorption, as these forms are primarily absorbed in the gastrointestinal tract 27.Ĭyanocobalamin corrects vitamin B12 deficiency and improves the symptoms and laboratory abnormalities associated with pernicious anemia (megaloblastic indices, gastrointestinal lesions, and neurologic damage). Dose requirements for vitamin B12 which are higher than normal (caused by pregnancy, thyrotoxicosis, hemolytic anemia, hemorrhage, malignancy, hepatic and renal disease) can usually be achieved with oral supplementation 20. Vitamin B12 supplements are widely available and indicated in patients who require supplementation for various reasons. Gastrointestinal pathology, dysfunction, or surgery, including gluten enteropathy or sprue, small bowel bacterial overgrowth, total or partial gastrectomy Vitamin B12 deficiency is frequently caused by malabsorption, which is often associated with the following conditions 20: These forms are indicated for vitamin B12 deficiencies due to various causes, with or without neurologic manifestations 26. Injection forms (subcutaneous, intramuscular) Note: CaloMist Label, the nasal spray form, has not been evaluated for the treatment of newly diagnosed vitamin B12 deficiency. The cyanocobalamin nasal spray is indicated for the maintenance of vitamin B12 concentrations after normalization with intramuscular vitamin B12 therapy in patients with deficiency of this vitamin who have no nervous system involvement Label. Type Small Molecule Groups Approved, Nutraceutical Structure This drug was initially approved by the FDA in 1942 Label. Several pharmaceutical forms of cyanocobalamin have been developed, including the tablet, injection, and nasal spray forms Label, 19, 20.
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The cyano form, is the most widely used form in supplements and prescription drugs 10, Label.
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Vitamin B12 has many forms, including the cyano-, methyl-, deoxyadenosyl- and hydroxy-cobalamin forms. This vitamin is produced naturally by bacteria 16, and is necessary for DNA synthesis and cellular energy production.
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Animi-3 With Vitamin D, B-12, Cobex, Concept Ob, Dodex, Ferralet 90, Ferraplus, Folbic, Foltabs, Fortaplex, Hematogen, Infuvite, Infuvite Pediatric, Irospan 24/6 Kit, Mvc-fluoride, Mvi Pediatric, Nascobal, Natafort, Pregvit, Tandem Plus, Vitafol-one Generic Name CyanocobalaminĬommonly known or available as Vitamin B12 DrugBank Accession Number DB00115 BackgroundĬyanocobalamin (commonly known as Vitamin B12) is a highly complex, essential vitamin, owing its name to the fact that it contains the mineral, cobalt.